SERCA-2a is involved in the right ventricular function following myocardial infarction in rats

Right ventricular (RV) function is considered an independent predictor of mortality and development of heart failure (HF) in patients with left ventricle dysfunction following myocardial infarction (MI). The functional and molecular mechanisms that may explain the RV dysfunction are still poorly und...

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Published in:Life sciences (1973) 2015-03, Vol.124, p.24-30
Main Authors: Fernandes, Aurélia Araújo, Ribeiro, Rogério Faustino, de Moura, Viviane G.C., Siman, Fabiana Deise, Dias, Fernanda Moura Vargas, Zoghaib, Jorge, Vassallo, Paula Frizera, Vassallo, Dalton Valentim, Stefanon, Ivanita
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Gene Expression Regulation
Heart failure
Heart Failure - physiopathology
Isometric Contraction - physiology
Isoproterenol - pharmacology
Male
Myocardial contractility
Myocardial infarction
Myocardial Infarction - physiopathology
Rats
Rats, Wistar
Right ventricle
Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Right - physiology
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Summary:Right ventricular (RV) function is considered an independent predictor of mortality and development of heart failure (HF) in patients with left ventricle dysfunction following myocardial infarction (MI). The functional and molecular mechanisms that may explain the RV dysfunction are still poorly understood. Our study was conducted to investigate RV contractility and the myocardium protein involved in the calcium handling following MI in rats. MI was surgically induced in male Wistar rats to create transmural infarctions involving 40–60% of the left ventricle surface. Infarcted rats were divided into two groups: those that presented classical signs of congestive heart failure (HF group) and those that did not (INF group), and compared to control animals (Sham). RV contractility was studied using isometric contraction in isolated strips and isovolumetric pressure in isolated heart. Inotropic responses in RV strips were preserved in the INF group but were reduced in the HF group (3.75mM Ca2+ treatment: Sham=163±18; INF=148±19; HF=68±11g/g*; *p
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2015.01.010