Long-term consequences of Hodgkin lymphoma therapy on T-cell lymphopoiesis

[...]long after treatment, patients with HL exhibit a persistent and dramatic alteration in CD4+ T-cell homeostasis and in thymic function, evidenced by a decrease in naive thymic CD4+ CD45RA+ CD31+ T-cell numbers and TREC levels, while memory CD4+ T-cell counts remained unaffected.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2015-03, Vol.135 (3), p.818-820.e4
Main Authors: Pellier, Isabelle, MD, PhD, Renier, Gilles, MD, PhD, Rakotonjanahary, Josué, MPH, MSc, Audrain, Marie, PharmD, PhD, Berardi, Elsa, MSc, Gardembas, Martine, MD, Clavert, Aline, MD, Moles, Marie Pierre, MD, Proust-Houdemont, Stéphanie, MD, Reguerre, Yves, MD, De Carli, Emilie, MD, Georgin-Mege, Martine, MD, Garo, Erwan, Blanchard, Simon, Miot, Charline, PhD, Picard, Capucine, MD, PhD, Delneste, Yves, PhD, Fischer, Alain, MD, PhD, Tanguy-Schmidt, Aline, MD, Jeannin, Pascale, PharmD, PhD
Format: Article
Language:English
Subjects:
Adult
Age
Allergy and Immunology
Antineoplastic Agents - therapeutic use
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
B-Lymphocytes - pathology
B-Lymphocytes - radiation effects
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - pathology
CD4-Positive T-Lymphocytes - radiation effects
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - pathology
CD8-Positive T-Lymphocytes - radiation effects
Chemotherapy
Female
Gamma Rays - therapeutic use
Hodgkin Disease - immunology
Hodgkin Disease - pathology
Hodgkin Disease - therapy
Homeostasis
Humans
Immune system
Immunophenotyping
Infections
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
Killer Cells, Natural - pathology
Killer Cells, Natural - radiation effects
Lymphocytes
Lymphopoiesis - drug effects
Lymphopoiesis - immunology
Lymphopoiesis - radiation effects
Male
Middle Aged
Multivariate analysis
Neoplasm Staging
Prospective Studies
Radiation therapy
Thymus Gland - drug effects
Thymus Gland - immunology
Thymus Gland - pathology
Thymus Gland - radiation effects
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Description
Summary:[...]long after treatment, patients with HL exhibit a persistent and dramatic alteration in CD4+ T-cell homeostasis and in thymic function, evidenced by a decrease in naive thymic CD4+ CD45RA+ CD31+ T-cell numbers and TREC levels, while memory CD4+ T-cell counts remained unaffected.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.08.048