Cation-chloride cotransporters: Regulation, physiological significance, and role in pathogenesis of arterial hypertension

This review summarizes the data on the functioning of carriers providing electroneutral symport of sodium, potassium, and chloride (Na + ,K + ,2Cl − cotransport), potassium and chloride (K + ,Cl − cotransport), and sodium and chloride (K + ,Cl − cotransport) as well as molecular mechanisms of the re...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2014-12, Vol.79 (13), p.1546-1561
Main Authors: Orlov, S. N., Koltsova, S. V., Kapilevich, L. V., Dulin, N. O., Gusakova, S. V.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Carrier proteins
Chloride
Chloride channels
Health aspects
Humans
Hypertension
Hypertension - etiology
Life Sciences
Microbiology
Pathogenesis
Physiological aspects
Potassium
Protein research
Protein-protein interactions
Review
Sodium
Sodium Chloride Symporters - physiology
Sodium-Potassium-Chloride Symporters - physiology
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Summary:This review summarizes the data on the functioning of carriers providing electroneutral symport of sodium, potassium, and chloride (Na + ,K + ,2Cl − cotransport), potassium and chloride (K + ,Cl − cotransport), and sodium and chloride (K + ,Cl − cotransport) as well as molecular mechanisms of the regulation of these carriers and their physiological significance. We emphasized the involvement of chloride-coupled carriers in the regulation of cell volume and intracellular chloride concentration and novel data on the role of ubiquitous isoform of Na + ,K + ,2Cl − cotransporter NKCC1 in regulation of vascular smooth muscle contraction and activity of GABA A receptors. Finally, we analyzed the data on activation of NKCC1 in patients with essential hypertension and its role in the long-term maintenance of elevated systemic blood pressure and myogenic response in microcirculatory beds.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297914130070