Acid-sensing ion channels and their modulators

According to a modern look acid-sensing ion channels (ASICs) are one of the most important receptors that perceive pH change in the body. ASICs represent proton-gated Na + -selective channels, which are expressed in neurons of the central and peripheral nervous system. These channels are attracting...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow) 2014-12, Vol.79 (13), p.1528-1545
Main Authors: Osmakov, D. I., Andreev, Ya. A., Kozlov, S. A.
Format: Article
Language:English
Subjects:
Acid Sensing Ion Channels - chemistry
Acid Sensing Ion Channels - drug effects
Acid Sensing Ion Channels - physiology
Analgesics - pharmacology
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Health aspects
Humans
Ion channels
Ions
Life Sciences
Ligands
Microbiology
Neurons - drug effects
Neurons - physiology
Neuroprotective Agents - pharmacology
Pain
Peptides
Perceptions
Physiological aspects
Protein research
Protein-protein interactions
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:According to a modern look acid-sensing ion channels (ASICs) are one of the most important receptors that perceive pH change in the body. ASICs represent proton-gated Na + -selective channels, which are expressed in neurons of the central and peripheral nervous system. These channels are attracting attention of researchers around the world, as they are involved in various physiological processes in the body. Drop of pH may occur in tissues in norm (e.g. the accumulation of lactic acid, the release of protons upon ATP hydrolysis) and pathology (inflammation, ischemic stroke, tissue damage and seizure). These processes are accompanied by unpleasant pain sensations, which may be short-lived or can lead to chronic inflammatory diseases. Modulators of ASIC channels activity are potential candidates for new effective analgesic and neuroprotection drugs. This review summarizes available information about structure, function, and physiological role of ASIC channels. In addition a description of all known ligands of these channels and their practical relevance is provided.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297914130069