Formation of silk fibroin hydrogel and evaluation of its drug release profile

ABSTRACT Silk hydrogels are interesting materials to be used as matrix in controlled drug delivery devices. However, methods to accelerate fibroin gelation and allow the drug incorporation during the hydrogel preparation are needed in literature. In this article we report the preparation of silk fib...

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Bibliographic Details
Published in:Journal of applied polymer science 2015-04, Vol.132 (15), p.np-n/a
Main Authors: de Moraes, Mariana Agostini, Albrecht Mahl, Cynthia Regina, Ferreira Silva, Mariana, Beppu, Marisa Masumi
Format: Article
Language:English
Subjects:
biopolymers and renewable polymers
Dissolution
Drug delivery systems
Drugs
Ethanol
Ethyl alcohol
Gelation
gels
Hydrogels
Materials science
Polymers
Silk fibroin
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Summary:ABSTRACT Silk hydrogels are interesting materials to be used as matrix in controlled drug delivery devices. However, methods to accelerate fibroin gelation and allow the drug incorporation during the hydrogel preparation are needed in literature. In this article we report the preparation of silk fibroin hydrogels with addition of several contents of ethanol, used to accelerate fibroin gelation kinetics, and we also evaluate the potential of these hydrogels to be used as matrices for drug delivery. Chemical and conformational properties did not change despite the amount of ethanol incorporated in the hydrogel. Hydrogels containing diclofenac sodium dissolved in ethanol showed a faster initial release of the drug than hydrogels with the drug dissolved in water but equilibrium was reached later. This indicates a more sustained drug delivery from hydrogels in which the model drug was dissolved in ethanol. Fibroin hydrogels confirm their promising use as biopolymeric matrices for controlled drug release. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41802.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.41802