Neuropsychological impact of cerebral microemboli in ablation of atrial fibrillation

Background Clinically silent lesions on cerebral magnet resonance imaging have been found in larger numbers after pulmonary vein isolation (PVI) especially with phased radio frequency (pRF) using all ten electrodes. However, the neuropsychological effects of cerebral microembolism during the procedu...

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Bibliographic Details
Published in:Clinical research in cardiology 2015-03, Vol.104 (3), p.234-240
Main Authors: Kochhäuser, S., Lohmann, H. H., Ritter, M. A., Leitz, P., Güner, F., Zellerhoff, S., Korsukewitz, C., Dechering, D. G., Banken, J., Peters, N. M., Eckardt, L., Mönnig, G.
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - diagnosis
Atrial Fibrillation - surgery
Cardiology
Catheter Ablation - adverse effects
Catheter Ablation - methods
Cognition
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cognition Disorders - psychology
Female
Germany
Humans
Intracranial Embolism - diagnosis
Intracranial Embolism - etiology
Intracranial Embolism - psychology
Male
Medicine
Medicine & Public Health
Middle Aged
Neuropsychological Tests
Original Paper
Predictive Value of Tests
Prospective Studies
Risk Factors
Therapeutic Irrigation - adverse effects
Time Factors
Treatment Outcome
Ultrasonography, Doppler, Transcranial
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Summary:Background Clinically silent lesions on cerebral magnet resonance imaging have been found in larger numbers after pulmonary vein isolation (PVI) especially with phased radio frequency (pRF) using all ten electrodes. However, the neuropsychological effects of cerebral microembolism during the procedure remain unclear and data regarding this issue so far are inconsistent. Methods Between August 2011 and June 2012, 76 patients undergoing their first PVI were randomized to ablation with either phased (40) or irrigated (36) radio frequency (iRF). A comprehensive neuropsychological test battery was performed the day before and after PVI as well as 6 months after ablation. The occurrence of cerebral microemboli during the procedure was performed via a transcranial Doppler ultrasound device. Results PVI using pRF was associated with increased number of microembolic signals (MES) compared to iRF (1530.0 ± 979.8 vs. 645.7 ± 448.7; p  
ISSN:1861-0684
1861-0692
DOI:10.1007/s00392-014-0777-0