Sarcopenia in COPD: prevalence, clinical correlates and response to pulmonary rehabilitation

Background Age-related loss of muscle, sarcopenia, is recognised as a clinical syndrome with multiple contributing factors. International European Working Group on Sarcopenia in Older People (EWGSOP) criteria require generalised loss of muscle mass and reduced function to diagnose sarcopenia. Both a...

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Bibliographic Details
Published in:Thorax 2015-03, Vol.70 (3), p.213-218
Main Authors: Jones, Sarah E, Maddocks, Matthew, Kon, Samantha S C, Canavan, Jane L, Nolan, Claire M, Clark, Amy L, Polkey, Michael I, Man, William D-C
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Atrophy
Body Composition
Case-Control Studies
Chronic obstructive pulmonary disease
Dyspnea
Exercise
Exercise Tolerance
Female
Fitness training programs
Gender
Health Status
Humans
Male
Middle Aged
Muscle Strength
Musculoskeletal system
Physical fitness
Prevalence
Propensity Score
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - physiopathology
Pulmonary Disease, Chronic Obstructive - rehabilitation
Quadriceps Muscle - physiopathology
Questionnaires
Rehabilitation
Sarcopenia
Sarcopenia - epidemiology
Sarcopenia - physiopathology
Sarcopenia - rehabilitation
Severity of Illness Index
Walking - physiology
Womens health
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Summary:Background Age-related loss of muscle, sarcopenia, is recognised as a clinical syndrome with multiple contributing factors. International European Working Group on Sarcopenia in Older People (EWGSOP) criteria require generalised loss of muscle mass and reduced function to diagnose sarcopenia. Both are common in COPD but are usually studied in isolation and in the lower limbs. Objectives To determine the prevalence of sarcopenia in COPD, its impact on function and health status, its relationship with quadriceps strength and its response to pulmonary rehabilitation (PR). Methods EWGSOP criteria were applied to 622 outpatients with stable COPD. Body composition, exercise capacity, functional performance, physical activity and health status were assessed. Using a case–control design, response to PR was determined in 43 patients with sarcopenia and a propensity score-matched non-sarcopenic group. Results Prevalence of sarcopenia was 14.5% (95% CI 11.8% to 17.4%), which increased with age and Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) stage, but did not differ by gender or the presence of quadriceps weakness (14.9 vs 13.8%, p=0.40). Patients with sarcopenia had reduced exercise capacity, functional performance, physical activity and health status compared with patients without sarcopenia (p
ISSN:0040-6376
1468-3296
DOI:10.1136/thoraxjnl-2014-206440