Subthalamic deep brain stimulation improves auditory sensory gating deficit in Parkinson’s disease

Highlights • Stimulus rate-dependent amplitude suppression of the auditory P1/N1-complex is impaired in patients with advanced Parkinson’s disease. • Dopaminergic treatment has no effect on these auditory sensory gating characteristics. • Deep brain stimulation of the subthalamic nucleus restores a...

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Bibliographic Details
Published in:Clinical neurophysiology 2015-03, Vol.126 (3), p.565-574
Main Authors: Gulberti, A, Hamel, W, Buhmann, C, Boelmans, K, Zittel, S, Gerloff, C, Westphal, M, Engel, A.K, Schneider, T.R, Moll, C.K.E
Format: Article
Language:English
Subjects:
Aged
Antiparkinson Agents - pharmacology
Antiparkinson Agents - therapeutic use
Auditory Cortex - drug effects
Auditory Cortex - physiopathology
Auditory evoked potentials
Combined Modality Therapy
Deep Brain Stimulation
Electroencephalography
Evoked Potentials, Auditory - drug effects
Evoked Potentials, Auditory - physiology
Female
Humans
Levodopa - pharmacology
Levodopa - therapeutic use
Male
Middle Aged
Neurology
Parkinson Disease - drug therapy
Parkinson Disease - physiopathology
Parkinson’s disease
Sensory gating
Sensory Gating - drug effects
Sensory Gating - physiology
Subthalamic nucleus
Subthalamic Nucleus - drug effects
Subthalamic Nucleus - physiopathology
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Summary:Highlights • Stimulus rate-dependent amplitude suppression of the auditory P1/N1-complex is impaired in patients with advanced Parkinson’s disease. • Dopaminergic treatment has no effect on these auditory sensory gating characteristics. • Deep brain stimulation of the subthalamic nucleus restores a physiological P1/N1-amplitude attenuation profile and may improve early attentive filtering processes possibly at the level of the frontal cortex.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2014.06.046