Role of Rifampin for Treatment of Orthopedic Implant–Related Staphylococcal Infections : A Randomized Controlled Trial

CONTEXT.— Rifampin-containing regimens are able to cure staphylococcal implant-related infections based on in vitro and in vivo observations. However, this evidence has not been proven by a controlled clinical trial. OBJECTIVE.— To evaluate the clinical efficacy of a rifampin combination in staphylo...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 1998-05, Vol.279 (19), p.1537-1541
Main Authors: Zimmerli, Werner, Widmer, Andreas F, Blatter, Marianne, Frei, R, Ochsner, Peter E, for the Foreign-Body Infection (FBI) Study Group
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Infections
Medical sciences
Orthopedic apparatus
Pharmacology. Drug treatments
Staphylococcus
Transplants & implants
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Summary:CONTEXT.— Rifampin-containing regimens are able to cure staphylococcal implant-related infections based on in vitro and in vivo observations. However, this evidence has not been proven by a controlled clinical trial. OBJECTIVE.— To evaluate the clinical efficacy of a rifampin combination in staphylococcal infections associated with stable orthopedic devices. DESIGN.— A randomized, placebo-controlled, double-blind trial conducted from 1992 through 1997. SETTING.— Two infectious disease services in tertiary care centers in collaboration with 5 orthopedic surgeons in Switzerland. PATIENTS.— A total of 33 patients with culture-proven staphylococcal infection associated with stable orthopedic implants and with a short duration of symptoms of infection (exclusion limit
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.279.19.1537