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Role of Rifampin for Treatment of Orthopedic Implant–Related Staphylococcal Infections : A Randomized Controlled Trial
CONTEXT.— Rifampin-containing regimens are able to cure staphylococcal implant-related infections based on in vitro and in vivo observations. However, this evidence has not been proven by a controlled clinical trial. OBJECTIVE.— To evaluate the clinical efficacy of a rifampin combination in staphylo...
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Published in: | JAMA : the journal of the American Medical Association 1998-05, Vol.279 (19), p.1537-1541 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | CONTEXT.—
Rifampin-containing regimens are able to cure staphylococcal implant-related
infections based on in vitro and in vivo observations. However, this evidence
has not been proven by a controlled clinical trial.
OBJECTIVE.—
To evaluate the clinical efficacy of a rifampin combination in staphylococcal
infections associated with stable orthopedic devices.
DESIGN.—
A randomized, placebo-controlled, double-blind trial conducted from
1992 through 1997.
SETTING.—
Two infectious disease services in tertiary care centers in collaboration
with 5 orthopedic surgeons in Switzerland.
PATIENTS.—
A total of 33 patients with culture-proven staphylococcal infection
associated with stable orthopedic implants and with a short duration of symptoms
of infection (exclusion limit |
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ISSN: | 0098-7484 1538-3598 |
DOI: | 10.1001/jama.279.19.1537 |