Peripheral artery disease is a coronary heart disease risk equivalent among both men and women: results from a nationwide study

Aims Lower extremity peripheral artery disease (PAD) has been proposed as a ‘coronary heart disease (CHD) risk equivalent’. We aimed to examine whether PAD confers similar risk for mortality as incident myocardial infarction (MI) and whether risk differs by gender. Methods Using nationwide Danish ad...

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Bibliographic Details
Published in:European journal of preventive cardiology 2015-03, Vol.22 (3), p.317-325
Main Authors: Subherwal, Sumeet, Patel, Manesh R, Kober, Lars, Peterson, Eric D, Bhatt, Deepak L, Gislason, Gunnar H, Olsen, Anne-Marie Schjerning, Jones, William S, Torp-Pedersen, Christian, Fosbol, Emil L
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Comorbidity
Denmark - epidemiology
Female
Humans
Incidence
Kaplan-Meier Estimate
Lower Extremity - blood supply
Male
Middle Aged
Myocardial Infarction - diagnosis
Myocardial Infarction - epidemiology
Myocardial Infarction - mortality
Peripheral Arterial Disease - diagnosis
Peripheral Arterial Disease - epidemiology
Peripheral Arterial Disease - mortality
Proportional Hazards Models
Registries
Risk Assessment
Risk Factors
Sex Factors
Time Factors
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Summary:Aims Lower extremity peripheral artery disease (PAD) has been proposed as a ‘coronary heart disease (CHD) risk equivalent’. We aimed to examine whether PAD confers similar risk for mortality as incident myocardial infarction (MI) and whether risk differs by gender. Methods Using nationwide Danish administrative registries (2000–2008), we identified patients aged ≥40 years with incident PAD (PAD only, n = 35,628), incident PAD with a history of MI (PAD + MI, n = 7029), and incident MI alone (MI alone, n = 71,115). Results Patients with PAD only tended to be younger, female, and have less comorbidity than the other groups. During follow up (median 1051 d, IQR 384–1938), we found that MI-alone patients had greater risk of adverse outcomes in the acute setting (first 90 d); however, the PAD-only and PAD + MI groups had higher long-term mortality at 7 years than those with MI alone (47.8 and 60.4 vs. 36.4%, respectively; p 
ISSN:2047-4873
2047-4881
DOI:10.1177/2047487313519344