Changes of Migraine-Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study

Objective/Background The aim of this longitudinal study was to investigate changes of migraine‐related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensitie...

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Bibliographic Details
Published in:Headache 2015-01, Vol.55 (1), p.55-70
Main Authors: Erdélyi-Bótor, Szilvia, Aradi, Mihály, Kamson, David Olayinka, Kovács, Norbert, Perlaki, Gábor, Orsi, Gergely, Nagy, Szilvia Anett, Schwarcz, Attila, Dóczi, Tamás, Komoly, Sámuel, Deli, Gabriella, Trauninger, Anita, Pfund, Zoltán
Format: Article
Language:English
Subjects:
Adult
Aged
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Attention Deficit Hyperactivity Disorder
brain white matter hyperintensity
Creatine - metabolism
Diffusion Magnetic Resonance Imaging
Drug therapy
Female
Frontal Lobe - metabolism
Frontal Lobe - pathology
Functional Laterality
Headaches
Humans
Inositol - metabolism
Leukoencephalopathies - etiology
Leukoencephalopathies - pathology
longitudinal analysis
Longitudinal Studies
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Middle Aged
migraine
Migraine Disorders - complications
NMR
Nuclear magnetic resonance
Patients
Protons
quantitative 3.0-Tesla MRI
Studies
volumetry
Young Adult
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Summary:Objective/Background The aim of this longitudinal study was to investigate changes of migraine‐related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes. Since in this patient group the repeated migraine attacks were the only known risk factors for the development of white matter hyperintensities, the remeasurements of migraineurs after a 3‐year long follow‐up may show changes in the status of these structural abnormalities as the effects of the repeated headaches. Methods The same patient group was reinvestigated in 2012 using the same MRI scanner and acquisition protocol. MR measurements were performed on a 3.0‐Tesla clinical MRI scanner. Beyond the routine T1‐, T2‐weighted, and fluid‐attenuated inversion recovery imaging, diffusion and perfusion‐weighted imaging, proton magnetic resonance spectroscopy, and T1 and T2 relaxation time measurements were also performed. Findings of the baseline and follow‐up studies were compared with each other. Results The follow‐up proton magnetic resonance spectroscopy studies of white matter hyperintensities showed significantly decreased N‐acetyl‐aspartate (median values 8.133 vs 7.153 mmol/L, P = .009) and creatine/phosphocreatine (median values 4.970 vs 4.641 mmol/L, P = .015) concentrations compared to the baseline, indicating a more severe axonal loss and glial hypocellularity with decreased intracellular energy production. The diffusion values, the T1 and T2 relaxation times, and the cerebral blood flow and volume measurements presented only mild changes between the studies. The number (median values 21 vs 25, P 
ISSN:0017-8748
1526-4610
DOI:10.1111/head.12459