The antiviral activity of cyclopentane β,β′-triketones related to secondary metabolites of higher plants

The effect of 20 cyclopentane β,β′-triketones and their sodium salts on the development of infections caused by tobacco mosaic virus (TMV) in leaves of tobacco ( Nicotiana tabacum L. cv. Xanthi-nc) has been studied. It has been shown that the strongest antiviral effect is produced by sodium salts of...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2014-12, Vol.40 (7), p.796-799
Main Authors: Lapshina, L. A., Shestak, O. P., Reunov, A. V., Novikov, V. L.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Low-Molecular-Weight Compounds
Nicotiana tabacum
Organic Chemistry
Tobacco mosaic virus
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Summary:The effect of 20 cyclopentane β,β′-triketones and their sodium salts on the development of infections caused by tobacco mosaic virus (TMV) in leaves of tobacco ( Nicotiana tabacum L. cv. Xanthi-nc) has been studied. It has been shown that the strongest antiviral effect is produced by sodium salts of 2-acetyl-4,7-dithio-2,3,4,5,6,7-hexahydro-1 H -inden-1,3-dione, 2-acetyl-4-oxa-7-thio-2,3,4,5,6,7-hexahydro-1 H -inden-1,3-dione, and 2-acetyl-4,5-didodecylthiocyclopent-4-en-1,3-dione. These compounds at a concentration of 2 mg/mL decrease the number of local TMV-induced necroses formed on inoculated tobacco leaves by 98% and have no toxic effect on leaf tissues.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162014070085