Distinct phenotypic features of neonatal murine macrophages

Neonates rely on their innate immune system. Resident tissue macrophages are considered to be initiators and regulators of the innate immune response and thus, appear to be especially important to neonates. We hypothesized that the phenotype and function of neonatal tissue macrophages differ from th...

Full description

Saved in:
Bibliographic Details
Published in:European journal of immunology 2015-01, Vol.45 (1), p.214-224
Main Authors: Winterberg, Thomas, Vieten, Gertrud, Meier, Tatiana, Yu, Yi, Busse, Mandy, Hennig, Christian, Hansen, Gesine, Jacobs, Roland, Ure, Benno M., Kuebler, Joachim F.
Format: Article
Language:English
Subjects:
Aging - immunology
Animals
Animals, Newborn
Antigens, Differentiation - genetics
Antigens, Differentiation - immunology
B7-1 Antigen - deficiency
B7-1 Antigen - genetics
B7-1 Antigen - immunology
B7-2 Antigen - deficiency
B7-2 Antigen - genetics
B7-2 Antigen - immunology
Cell Proliferation
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Immune responses
Immune system
Immunity, Innate
Immunophenotyping
Lipopolysaccharides - pharmacology
Macrophage Activation - drug effects
Macrophages
Macrophages, Peritoneal - cytology
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - immunology
Medical research
Mice
Mice, Inbred C57BL
Neonate immunity
Phenotype
Primary Cell Culture
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Toll‐like receptors (TLRs)
Transcriptome - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neonates rely on their innate immune system. Resident tissue macrophages are considered to be initiators and regulators of the innate immune response and thus, appear to be especially important to neonates. We hypothesized that the phenotype and function of neonatal tissue macrophages differ from their adult counterparts. Peritoneal macrophages from neonatal (
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201444468