Resistance Training Reduces Subclinical Inflammation in Obese, Postmenopausal Women

Aerobic exercise is frequently prescribed to reduce inflammatory-related disease (cardiovascular disease and diabetes) risk. Resistance training (RT), however, may be key to maximizing anti-inflammatory benefits of consistent exercise. We examined the influence of RT on inflammatory biomarkers in ob...

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Published in:Medicine and science in sports and exercise 2012-11, Vol.44 (11), p.2099-2110
Main Authors: PHILLIPS, Melody D, PATRIZI, Robert M, CHEEK, Dennis J, WOOTEN, Joshua S, BARBEE, James J, MITCHELL, Joel B
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers - blood
Body Constitution
C-Reactive Protein
Chemokine CCL2 - blood
Female
Fundamental and applied biological sciences. Psychology
Gene Expression
Humans
Inflammation - blood
Inflammation - diagnosis
Inflammation - prevention & control
Inflammation Mediators - blood
Interleukin-10 - blood
Interleukin-6 - blood
Lipopolysaccharides - blood
Middle Aged
Muscle Strength
Obesity - blood
Postmenopause - blood
Resistance Training
Reverse Transcriptase Polymerase Chain Reaction
Space life sciences
Tumor Necrosis Factor-alpha - blood
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Summary:Aerobic exercise is frequently prescribed to reduce inflammatory-related disease (cardiovascular disease and diabetes) risk. Resistance training (RT), however, may be key to maximizing anti-inflammatory benefits of consistent exercise. We examined the influence of RT on inflammatory biomarkers in obese, postmenopausal women. Twenty-three women (65.6 ± 2.6 yr; body mass index, 33 kg·m) underwent 12 wk of RT (3 sets, 10 exercises, 3× per week, 8-12 repetition maximum (RM), resistance exercise (EX), N = 11) or social interaction intervention (SI, stretching, knitting, health lectures, 2× per week, control group (CON), N = 12). Both before (BT) and after (AT) RT or SI, blood was collected before (PR), immediately (PO), 2 h (2H), and 24 h (24H) after a single resistance exercise bout (RE) in EX and at the same time points in nonexercise, resting CON. For all time points, blood was analyzed for IL-6, leptin, and lipopolysaccharide (LPS)-stimulated tumor necrosis factor-α (TNF-α) (LPS-TNF) and IL-10 (LPS-IL10). PR samples were also examined for C-reactive protein, TNF-α, and adiponectin, and mRNA expression of toll-like receptor 4 (TLR4) and MC1R. Subcutaneous adipose tissue was extracted BT and AT and analyzed for mRNA expression of monocyte chemotactic protein-1, leptin, CD68, and TLR4. RT improved strength (44%) and reduced circulating C-reactive protein (-33%), leptin (-18%) and TNF-α (-29%) with no change in body composition. IL-6 decreased after SI in CON (-17%). LPS-TNF increased after SI or RT (CON +26%, EX +67%, respectively), whereas LPS-IL10 decreased in CON (-28%) but increased in EX (+20%). RT did not influence inflammatory biomarker gene expression in whole blood or subcutaneous adipose tissue. A single RE bout augmented LPS-TNF and LPS-IL10 at 24H in EX, particularly AT. RT reduced markers of subclinical inflammation in circulation in obese, postmenopausal women in the absence of changes in body composition. Chronic RT also enhanced response to endotoxin challenge both at rest (PR) and 24 h after an acute RE bout (24H).
ISSN:0195-9131
1530-0315
DOI:10.1249/MSS.0b013e3182644984