Linearized hepatitis B surface antigen and hepatitis B core-related antigen in the natural history of chronic hepatitis B

Changes in two novel HBV serological markers, linearized hepatitis B surface antigen (HQ-HBsAg) and hepatitis B core-related antigen (HBcrAg), in the natural history of chronic hepatitis B (CHB) have not been well characterized. Serum HQ-HBsAg and HBcrAg levels of 404 Asian treatment-naïve CHB patie...

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Published in:	Clinical microbiology and infection 2014-11, Vol.20 (11), p.1173-1180
Main Authors:	Seto, W.-K., Wong, D. K.-H., Fung, J., Huang, F.-Y., Liu, K. S.-H., Lai, C.-L., Yuen, M.-F.
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Cohort Studies Cross-Sectional Studies Female HBcrAg HBsAg HBV Hepatitis B Core Antigens - blood Hepatitis B Surface Antigens - blood Hepatitis B virus Hepatitis B virus - isolation & purification Hepatitis B, Chronic - virology HQ-HBsAg Humans Male Middle Aged serology Viral Load Young Adult
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Summary:	Changes in two novel HBV serological markers, linearized hepatitis B surface antigen (HQ-HBsAg) and hepatitis B core-related antigen (HBcrAg), in the natural history of chronic hepatitis B (CHB) have not been well characterized. Serum HQ-HBsAg and HBcrAg levels of 404 Asian treatment-naïve CHB patients were analysed in a cross-sectional manner. Patients were categorized into five groups: immune tolerant (IT group, n = 52), immune clearance (IC group, n = 105), hepatitis B e antigen (HBeAg)-negative hepatitis (ENH group, n = 97), HBeAg-negative quiescent group (ENQ group, n = 95) and CHB with hepatitis B surface antigen (HBsAg) seroclearance (SC group, n = 55). HQ-HBsAg and HBcrAg were measured and correlated with HBV DNA, HBsAg, HBV genotype and clinical parameters. HQ-HBsAg showed good correlation with HBsAg, especially in the ENQ group (r = 0.874, p
ISSN:	1198-743X 1469-0691