Serum sRAGE as a Potential Biomarker for Pediatric Bronchiolitis: A Pilot Study

Purpose Traditional inflammatory biomarkers are insufficient for the evaluation of bronchiolitis severity. Recent investigations have shown that the receptor for advanced glycation end product (RAGE) and its soluble isoforms (sRAGE) play a critical role in the pathogenesis of lung injury. Main objec...

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Bibliographic Details
Published in:Lung 2015-02, Vol.193 (1), p.19-23
Main Authors: García-Salido, Alberto, Oñoro, Gonzalo, Melen, Gustavo J., Gómez-Piña, Vanesa, Serrano-González, Ana, Ramírez-Orellana, Manuel, Casado-Flores, Juan
Format: Article
Language:English
Subjects:
Advanced glycation end products
Age Factors
Biomarkers
Biomarkers - blood
Bronchiolitis
Bronchiolitis - blood
Bronchiolitis - diagnosis
Bronchitis
Care and treatment
Case-Control Studies
Child, Preschool
Diagnosis
Female
Genetic aspects
Humans
Infant
Infant, Newborn
Inflammatory diseases
Intensive Care Units, Pediatric
Length of Stay
Lung diseases
Male
Measurement
Medicine
Medicine & Public Health
Membrane proteins
Patient Admission
Pediatrics
Physiological aspects
Pilot Projects
Pneumology/Respiratory System
Predictive Value of Tests
Prognosis
Prospective Studies
Receptor for Advanced Glycation End Products
Receptors, Immunologic - blood
Severity of Illness Index
Time Factors
Up-Regulation
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Summary:Purpose Traditional inflammatory biomarkers are insufficient for the evaluation of bronchiolitis severity. Recent investigations have shown that the receptor for advanced glycation end product (RAGE) and its soluble isoforms (sRAGE) play a critical role in the pathogenesis of lung injury. Main objective was to assess the serum levels of sRAGE of children with severe bronchiolitis admitted to the pediatric intensive care unit (PICU). Secondary objective was to study sRAGE correlation with the evolution and traditional biomarkers. Methods Prospective, observational and descriptive study, 43 healthy controls and 37 patients (December 2011–February 2012) were enrolled. sRAGE levels were assessed and compared. In patients, the relation between sRAGE levels and clinical evolution, respiratory assistance, white blood cell count, absolute neutrophils count, serum C-reactive protein, and serum procalcitonin was analyzed. Results A statistical difference was found in the mean value of sRAGE at PICU admission between patients and controls (1,215.7 ± 535 vs 849 ± 579 pg/ml). Also a significant inverse correlation was found between sRAGE and the Wood–Downes Score at admission ( p  = 0.02). Conclusions Serum sRAGE could be elevated in children with bronchiolitis. Larger clinical studies are necessary to elucidate its role as a bronchiolitis inflammatory and/or lung injury biomarker.
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-014-9663-9