Assessment of Evidence for Positive Association and Seroprevalence of Hepatitis B and C in Diabetic Patients in a Developing Country

Background and AimThe data related to the association between hepatitis virus infections and diabetes mellitus (DM) are conflicting. The aim of this study was to investigate the seroprevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) and to determine the risk factors affecting the prev...

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Bibliographic Details
Published in:Journal of investigative medicine 2015-02, Vol.63 (2), p.251-257
Main Authors: Korkmaz, Huseyin, Kesli, Recep, Onder Pamuk, Barıs, Ipekci, Suleyman Hilmi, Terzi, Yuksel, Kebapcilar, Levent
Format: Article
Language:English
Subjects:
Developing Countries - statistics & numerical data
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 2 - complications
Female
Hepatitis B - blood
Hepatitis B - complications
Hepatitis B - epidemiology
Hepatitis C - blood
Hepatitis C - complications
Hepatitis C - epidemiology
Humans
Male
Middle Aged
Seroepidemiologic Studies
Turkey - epidemiology
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Summary:Background and AimThe data related to the association between hepatitis virus infections and diabetes mellitus (DM) are conflicting. The aim of this study was to investigate the seroprevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) and to determine the risk factors affecting the prevalence in Turkish patients with type 1 DM and type 2 DM.MethodsThe study consisted of 736 diabetic and 505 nondiabetic patients. Serological investigation for the hepatitis B surface antigen (HBsAg) and the HCV antibody (anti-HCV) was performed with a third-generation commercial chemiluminescence assay. The presence of HBsAg was considered as indicator of HBV infection. The HCV infection in the patients with positive anti-HCV was confirmed by a real-time polymerase chain reaction assay. The patients were divided according to their HBV and HCV infection status, and their demographic features, diabetes properties, general risk factors, and aminotransferase levels were analyzed.ResultsThere was no significant difference in the seropositivity rate for the HBsAg (3.8% vs 3.0%, P > 0.43; odds ratio, 1.292; 95% confidence interval, 0.683–2.444). However, anti-HCV seropositivity was significantly increased in the DM group (3.3% vs 1.8%, P < 0.03; odds ratio, 2.398; 95% confidence interval, 1.025–5.609). Increased aminotransferase levels and a history of blood transfusions were positively correlated with both HBV and HCV infection. Moreover, a history of surgical procedures and high glycated hemoglobin A1c levels were positively associated with HBsAg antigen seropositivity.ConclusionsAlthough no significant difference in the seropositivity of the HBsAg was determined, a high prevalence of HCV infection was detected in the DM patients compared to healthy controls.
ISSN:1081-5589
1708-8267
DOI:10.1097/JIM.0000000000000126