Cost-effectiveness of the ketogenic diet and vagus nerve stimulation for the treatment of children with intractable epilepsy

Highlights • We modeled three treatment options (KD, VNS and CAU) for refractory epilepsy. • From an economic viewpoint, CAU is the optimal treatment at 12 months. • However, VNS and KD should not be ignored as a treatment option. • There is great need for large high quality studies to identify resp...

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Bibliographic Details
Published in:Epilepsy research 2015-02, Vol.110, p.119-131
Main Authors: de Kinderen, Reina JA, Postulart, Debby, Aldenkamp, Albert P, Evers, Silvia MAA, Lambrechts, Danielle AJE, Louw, Anton JA de, Majoie, Marian HJM, Grutters, Janneke PC
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Cost-Benefit Analysis
Diet, Ketogenic - economics
Economic evaluation
Epilepsy - economics
Epilepsy - therapy
Humans
Infant
Intractable epilepsy
Ketogenic diet
Markov Chains
Modeling
Models, Econometric
Neurology
QALY
Quality-Adjusted Life Years
Vagus nerve stimulation
Vagus Nerve Stimulation - economics
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Summary:Highlights • We modeled three treatment options (KD, VNS and CAU) for refractory epilepsy. • From an economic viewpoint, CAU is the optimal treatment at 12 months. • However, VNS and KD should not be ignored as a treatment option. • There is great need for large high quality studies to identify responding subgroups. • It is wise to include a broader assessment of effectiveness (e.g. QOL) in trials.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2014.12.005