A Maternal High Fat Diet Has Long-Lasting Effects on Skeletal Muscle Lipid and PLIN Protein Content in Rat Offspring at Young Adulthood

A maternal high fat diet (HFD) can have adverse effects on skeletal muscle development. Skeletal muscle PLIN proteins (PLIN2, 3 and 5) are thought to play critical roles in lipid metabolism, however effects of HFD on PLIN and lipases (HSL, ATGL, CGI-58) in mothers as well as their offspring have yet...

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Bibliographic Details
Published in:Lipids 2015-02, Vol.50 (2), p.205-217
Main Authors: MacPherson, Rebecca E. K., Castelli, Laura M., Miotto, Paula M., Frendo-Cumbo, Scott, Milburn, Amanda, Roy, Brian D., LeBlanc, Paul J., Ward, Wendy E., Peters, Sandra J.
Format: Article
Language:English
Subjects:
ADRP
Animals
Biomedical and Life Sciences
Diet, High-Fat - adverse effects
Female
High fat diet
Life Sciences
Lipid Metabolism
Lipidology
Lipids - analysis
Male
Maternal diet
Medical Biochemistry
Medicinal Chemistry
Microbial Genetics and Genomics
Muscle, Skeletal - metabolism
Neurochemistry
Nutrition
Original Article
OXPAT
Perilipin-5
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Proteins - analysis
Proteins - metabolism
Rats - growth & development
Rats - metabolism
Skeletal muscle
TIP47
Triglycerides - analysis
Triglycerides - metabolism
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Summary:A maternal high fat diet (HFD) can have adverse effects on skeletal muscle development. Skeletal muscle PLIN proteins (PLIN2, 3 and 5) are thought to play critical roles in lipid metabolism, however effects of HFD on PLIN and lipases (HSL, ATGL, CGI-58) in mothers as well as their offspring have yet to be investigated. The primary objective of this study was to determine whether maternal HFD would influence skeletal muscle lipase and PLIN protein content in offspring at weaning (19d) and young adulthood (3mo). Female rats (28d old, n  = 9/group) were fed control (CON, AIN93G, 7 % soybean oil) or HFD (AIN93G, 20 % lard) for 10 weeks prior to mating and throughout pregnancy and lactation. All offspring were weaned to CON [ n  = 18/group, 1 female and 1 male pup per litter were studied at weaning (19d) and 3mo of age]. There was no effect of sex for the main outcomes measured in plantaris, therefore male and female data was combined. Maternal HFD resulted in higher triacylglycerol content in pups at 3mo ( p  
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-014-3985-5