Herbal medicine (Gan Mai Da Zao decoction) for depression: A systematic review and meta-analysis of randomized controlled trials

Highlights • Gan Mai Da Zao (GMDZ) decoction is one of the most famous Chinese herbal medicine for depression. • One recent systematic review of GMDZ decoction suggested that GMDZ might be beneficial as anti-depressants. However, this review analysis inappropriate and the information was not complet...

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Bibliographic Details
Published in:Maturitas 2014-12, Vol.79 (4), p.370-380
Main Authors: Jun, Ji Hee, Choi, Tae-Young, Lee, Ju Ah, Yun, Kyung-Jin, Lee, Myeong Soo
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Chinese herbal medicine
Depression
Depressive Disorder, Major - drug therapy
Drugs, Chinese Herbal - therapeutic use
Gan Mai Da Zao (GMDZ) decoction
General pharmacology
Glycyrrhiza uralensis
Gynecology. Andrology. Obstetrics
Health Services for the Aged
Humans
Internal Medicine
Medical sciences
Mood disorders
Obstetrics and Gynecology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Puberal and climacteric disorders (male and female)
Randomized Controlled Trials as Topic
Republic of Korea
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Summary:Highlights • Gan Mai Da Zao (GMDZ) decoction is one of the most famous Chinese herbal medicine for depression. • One recent systematic review of GMDZ decoction suggested that GMDZ might be beneficial as anti-depressants. However, this review analysis inappropriate and the information was not complete. • Thirteen RCTs met our inclusion criteria. All of the included RCTs had a high risk of bias across their domains. • Our systematic review and meta-analysis failed to provide suggestive evidence of the superiority of GMDZ decoction over anti-depressant therapies for major depression, post-surgical depression, and elderly depression except stroke depression.
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2014.08.008