Normal esophageal pressure topography metrics for data derived from the Sandhill‐Unisensor high‐resolution manometry assembly in supine and sitting positions

Background Normal values of the esophageal motor function parameters for high‐resolution manometry (HRM‐EPT) adopted by the Chicago classification were established using the proprietary system of Given Imaging. It is conceivable that normal values of a system do not apply to data from others. Most s...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2015-02, Vol.27 (2), p.285-292
Main Authors: Carmo, G. C., Jafari, J., Sifrim, D., Oliveira, R. B.
Format: Article
Language:English
Subjects:
Adult
Aged
Deglutition
esophagus
Esophagus - physiology
Female
high‐resolution manometry
Humans
Image Interpretation, Computer-Assisted - methods
Male
Manometry - instrumentation
Middle Aged
normal values
Peristalsis
position
Posture
Young Adult
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Summary:Background Normal values of the esophageal motor function parameters for high‐resolution manometry (HRM‐EPT) adopted by the Chicago classification were established using the proprietary system of Given Imaging. It is conceivable that normal values of a system do not apply to data from others. Most studies using HRM were based on supine swallows, whereas deglutition occurs mostly in the upright position. We wished to establish normal values for HRM‐EPT parameters obtained with the Sandhill's HRM‐EPT system and compare the results in supine and sitting positions. Methods Sixty‐nine healthy volunteers, 38 females, median age 27 years, were included in this study. All underwent supine HRM, and 34 of them underwent sitting HRM, with at least 10 single 5‐mL swallows for analysis obtained in each position. Key Results The normal range (5–95th percentiles) for the following parameters was calculated: distal contractile integral (DCI), 606–4998 mmHg·s·cm; contractile front velocity (CFV), 2.0–6.5 cm/s; distal latency (DL), 5.1–8.8 s; intrabolus pressure (IBP), 1.9–17.6 mmHg; upper esophageal sphincter (UES) pressure, 45.2–186.9 mmHg; esophagogastric junction (EGJ) length, 1.8–4 cm; EGJ resting pressure, 8.1–61.6 mmHg, and integrated relaxation pressure (IRP) 2.5–23.5 mmHg. Normal values of EGJ resting pressure, IRP, DCI, and IBP but not CFV, DL, and UES resting pressure were significantly lower in the sitting posture. Conclusions & Inferences Studies performed with Sandhill's HRM‐EPT system should use its own specific normal data. Normal values should be established for different study We established normal values for HRM parameters from Western healthy volunteers (Brazilian and British) using the Sandhill‐Unisensor HRM system. Upper normal limits for IRP and LES resting pressure are higher than those used in the Chicago classification. As data on HRM in supine and sitting positions are scanty, we acquired HRM data in both conditions, and confirmed that the normal values of EGJ resting pressure, IRP, DCI, and IBP are significantly lower in the sitting than in the supine position.
ISSN:1350-1925
1365-2982
DOI:10.1111/nmo.12501