Identification of new SNPs in native South American populations by resequencing the Y chromosome

Abstract The Y-chromosomal genetic landscape of South America is relatively homogenous. The majority of native Amerindian people are assigned to haplogroup Q and only a small percentage belongs to haplogroup C. With the aim of further differentiating the major Q lineages and thus obtaining new insig...

Full description

Saved in:
Bibliographic Details
Published in:Forensic science international : genetics 2015-03, Vol.15, p.111-114
Main Authors: Geppert, M, Ayub, Q, Xue, Y, Santos, S, Ribeiro-dos-Santos, Â, Baeta, M, Núñez, C, Martínez-Jarreta, B, Tyler-Smith, C, Roewer, L
Format: Article
Language:English
Subjects:
Chromosomes, Human, Y
Humans
Indians, South American - genetics
Pathology
Polymorphism, Single Nucleotide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The Y-chromosomal genetic landscape of South America is relatively homogenous. The majority of native Amerindian people are assigned to haplogroup Q and only a small percentage belongs to haplogroup C. With the aim of further differentiating the major Q lineages and thus obtaining new insights into the population history of South America, two individuals, both belonging to the sub-haplogroup Q-M3, were analyzed with next-generation sequencing. Several new candidate SNPs were evaluated and four were confirmed to be new, haplogroup Q-specific, and variable. One of the new SNPs, named MG2, identifies a new sub-haplogroup downstream of Q-M3; the other three (MG11, MG13, MG15) are upstream of Q-M3 but downstream of M242, and describe branches at the same phylogenetic positions as previously known SNPs in the samples tested. These four SNPs were typed in 100 individuals belonging to haplogroup Q.
ISSN:1872-4973
1878-0326
DOI:10.1016/j.fsigen.2014.09.014