Emerging role of CaMKII in neuropsychiatric disease

Highlights • Recent evidence for CaMKII dysregulation in psychiatric diseases is reviewed. • Changes in postsynaptic structure and function appear to be central to multiple diseases. • Altered regulation of the CaMKIIα gene promoter may be a common mechanism among diseases. • CaMKII dysregulation in...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2014-11, Vol.37 (11), p.653-662
Main Author: Robison, A.J
Format: Article
Language:English
Subjects:
addiction
Animals
Brain - metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism
CaMKII
depression
epilepsy
Epilepsy - psychology
Humans
Kinases
Learning
Memory
Mental disorders
Neurological disorders
Neurology
Neuronal Plasticity - physiology
Neurons - metabolism
Neurosciences
psychiatric disease
schizophrenia
Signal Transduction
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Summary:Highlights • Recent evidence for CaMKII dysregulation in psychiatric diseases is reviewed. • Changes in postsynaptic structure and function appear to be central to multiple diseases. • Altered regulation of the CaMKIIα gene promoter may be a common mechanism among diseases. • CaMKII dysregulation in diverse brain regions may account for myriad disorders.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2014.07.001