Circadian disruption in the pathogenesis of metabolic syndrome

Abstract Metabolic syndrome is a multifactorial process induced by a combination of genetic and environmental factors and recent evidence has highlighted that circadian disruption and sleep loss contribute to disease pathogenesis. Emerging work in experimental genetic models has provided insight int...

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Bibliographic Details
Published in:Diabetes & metabolism 2014-11, Vol.40 (5), p.338-346
Main Authors: Maury, E, Hong, H.K, Bass, J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiovascular disease
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Chronobiology
Circadian Rhythm
CLOCK Proteins - metabolism
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinology & Metabolism
Endocrinopathies
Energy Metabolism
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Glucose - metabolism
Homeostasis
Humans
Hypothalamus - metabolism
Inflammation - metabolism
Inflammation - physiopathology
Internal Medicine
Lipid Metabolism
Lipids - blood
Medical sciences
Metabolic diseases
Metabolic Syndrome - metabolism
Metabolic Syndrome - physiopathology
Metabolism
Miscellaneous
Other metabolic disorders
Signal Transduction
Sleep Deprivation - metabolism
Sleep Deprivation - physiopathology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Abstract Metabolic syndrome is a multifactorial process induced by a combination of genetic and environmental factors and recent evidence has highlighted that circadian disruption and sleep loss contribute to disease pathogenesis. Emerging work in experimental genetic models has provided insight into the mechanistic basis for clock disruption in disease. Indeed, disruption of the clock system perturbs both neuroendocrine pathways within the hypothalamus important in feeding and energetics, in addition to peripheral tissues involved in glucose and lipid metabolism. This review illustrates the impact of molecular clock disruptions at the level of both brain and behavior and peripheral tissues, with a focus on how such dysregulation in turn impacts lipid and glucose homeostasis, inflammation and cardiovascular function. New insight into circadian biology may ultimately lead to improved therapeutics for metabolic syndrome and cardiovascular disease in humans.
ISSN:1262-3636
1878-1780
DOI:10.1016/j.diabet.2013.12.005