Immobilisation of a fibrillin-1 fragment enhances the biocompatibility of PTFE

Current vascular biomaterials exhibit poor biocompatibility characterised by failure to promote endothelialisation, predisposition to neoinitmal hyperplasia and excessive thrombogenicity. Fibrillin-1, a major constituent of microfibrils is associated with elastic fibres in the arterial wall. Fibrill...

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Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-04, Vol.116, p.544-552
Main Authors: Hajian, Hamid, Wise, Steven G, Bax, Daniel V, Kondyurin, Alexey, Waterhouse, Anna, Dunn, Louise L, Kielty, Cay M, Yu, Young, Weiss, Anthony S, Bilek, Marcela M M, Bannon, Paul G, Ng, Martin K C
Format: Article
Language:English
Subjects:
Attachment
Biocompatibility
Biocompatible Materials - chemistry
Cell Adhesion
Cell Proliferation
Coating
Endothelial cells
Endothelial Cells - chemistry
Failure
Fibrillin-1
Fibrillins
Fragmentation
HEK293 Cells
Humans
Microfilament Proteins - chemistry
Polytetrafluoroethylene - chemistry
Polytetrafluoroethylenes
Recombinant
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Summary:Current vascular biomaterials exhibit poor biocompatibility characterised by failure to promote endothelialisation, predisposition to neoinitmal hyperplasia and excessive thrombogenicity. Fibrillin-1, a major constituent of microfibrils is associated with elastic fibres in the arterial wall. Fibrillin-1 binds to endothelial cells through an RGD cell adhesion motif in the fourth TB module. The RGD motif is present in PF8, a recombinant fibrillin-1 fragment. We investigated the potential of PF8 to improve the biocompatibility of PTFE. PF8 enhanced endothelial cell attachment and cell proliferation to a greater extent than fibronectin (p
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2014.01.042