Computational simulation and preparation of fluorescent magnetic molecularly imprinted silica nanospheres for ciprofloxacin or norfloxacin sensing

A magnetic molecularly imprinted fluorescent sensor for the sensitive and convenient determination of ciprofloxacin or norfloxacin in human urine was synthesized and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, ultraviolet/visible spectro...

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Bibliographic Details
Published in:Journal of separation science 2014-12, Vol.37 (24), p.3753-3759
Main Authors: Gao, Bo, He, Xin-Ping, Jiang, Yang, Wei, Jia-Tong, Suo, Hui, Zhao, Chun
Format: Article
Language:English
Subjects:
Analysis
Antibiotics
Biological and medical sciences
Cadmium
Cadmium Compounds - chemistry
Ciprofloxacin - urine
Computation
Ferric Compounds - chemistry
Fluorescence
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluoroquinolones
General pharmacology
Human
Humans
Magnetic Phenomena
Magnetic separation
Medical sciences
Molecular Dynamics Simulation
Molecular Imprinting
Molecular modeling
Molecular Structure
Nanospheres - chemistry
Norfloxacin
Norfloxacin - urine
Particle Size
Pharmacology. Drug treatments
Polymerization
Polymers - chemical synthesis
Polymers - chemistry
Quantum Dots
Separation
Silica
Silicon Dioxide - chemistry
Simulation
Spectrum analysis
Surface Properties
Tellurium - chemistry
Ultraviolet
Urine
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Summary:A magnetic molecularly imprinted fluorescent sensor for the sensitive and convenient determination of ciprofloxacin or norfloxacin in human urine was synthesized and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, ultraviolet/visible spectroscopy, and fluorescence spectroscopy. Both cadmium telluride quantum dots and ferroferric oxide nanoparticles are introduced into the polymer for the rapid separation and detection of the target molecules. The synthesized molecularly imprinted polymers were applied to detect ciprofloxacin or its structural analog norfloxacin in human urine with the detection limit 130 ng/mL. A computational study was developed to evaluate the template–monomer geometry and interaction energy in the polymerization mixture to determine the reaction molar ratio of the template and monomer molecules.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.201401014