Synthesis and Characterization of a Library of In-Situ Curing, Nonswelling Ethoxylated Polyol Thiol-ene Hydrogels for Tailorable Macromolecule Delivery

A transesterfication reaction is used to synthesize tri‐thiol‐functionalized‐ethoxylated polyols that are combined with polyethylene glycol diacrylates to form a biodegradable hydrogel library. Hydrogels display nonswelling equilibration and offer temporal control over material degradation and the r...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2015-01, Vol.27 (1), p.65-72
Main Authors: O'Shea, Timothy M., Aimetti, Alex A., Kim, Eunha, Yesilyurt, Volkan, Langer, Robert
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Balancing
Biocompatible Materials - chemical synthesis
Biocompatible Materials - therapeutic use
Biodegradability
candida antarctica lipase B
Cell Line
Cell Survival
Diffusion
drug delivery
Drug Delivery Systems
Hydrogels
Hydrogels - chemical synthesis
Hydrogels - therapeutic use
Kinetics
Libraries
Macromolecular Substances - administration & dosage
Macromolecular Substances - pharmacokinetics
Materials Testing
Permeability
Platforms
Polyethylene glycol
Polyethylene Glycols - chemistry
polymeric materials
Polymers - chemical synthesis
Polymers - therapeutic use
Polyols
Temperature
Temporal logic
thiol-michael addition
Tissue Scaffolds
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Summary:A transesterfication reaction is used to synthesize tri‐thiol‐functionalized‐ethoxylated polyols that are combined with polyethylene glycol diacrylates to form a biodegradable hydrogel library. Hydrogels display nonswelling equilibration and offer temporal control over material degradation and the release of biomolecules. The demonstrated in vitro biocompatibility makes this a versatile platform that can be used for local drug delivery to volume‐constrained anatomical sites.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201403724