Human T-lymphotropic virus type 2 subtype b in a patient with chronic neurological disorder

Introduction: Human T-cell lymphotropic virus is a retrovirus described worldwide. There are four HTLV types: HTLV-1 to 4. Only HTLV-1 and 2 are linked to human disease. The majority of infected individuals remain asymptomatic. However, it is estimated that 5 % of HTLV-1-infected patients present a...

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Bibliographic Details
Published in:Journal of neurovirology 2014-12, Vol.20 (6), p.636-639
Main Authors: Rosadas, Carolina, Vicente, Ana C. P., Zanella, Louise, Cabral-Castro, Mauro J., Peralta, José M., Puccioni-Sohler, Marzia
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Brazil
Case Report
Coinfection
Genotype
Hepacivirus - isolation & purification
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - physiopathology
Hepatitis C, Chronic - virology
HTLV-II Infections - diagnosis
HTLV-II Infections - physiopathology
HTLV-II Infections - virology
Human T-lymphotropic virus
Human T-lymphotropic virus 1
Human T-lymphotropic virus 2
Human T-lymphotropic virus 2 - classification
Human T-lymphotropic virus 2 - genetics
Human T-lymphotropic virus 2 - pathogenicity
Humans
Immunology
Infectious Diseases
Male
Middle Aged
Neurology
Neurosciences
Paraparesis, Tropical Spastic - diagnosis
Paraparesis, Tropical Spastic - physiopathology
Paraparesis, Tropical Spastic - virology
Phylogeny
Virology
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Summary:Introduction: Human T-cell lymphotropic virus is a retrovirus described worldwide. There are four HTLV types: HTLV-1 to 4. Only HTLV-1 and 2 are linked to human disease. The majority of infected individuals remain asymptomatic. However, it is estimated that 5 % of HTLV-1-infected patients present a clinical neurological disorder called HTLV-1-associated myelopathy (HAM/TSP) (Osame 1990). The diagnosis of HAM/TSP is made according to WHO criteria. The presence of specific antibodies in both blood and CSF, associated with slowly progressive spastic paraparesis, characterizes HAM/TSP (Osame 1990; Puccioni-Sohler et al. 2001). HTLV-1 infection has also been related with others neurologic manifestations, such as sensory neuropathy, cognitive deficit, myositis, erectile dysfunctions, and isolated bladder dysfunction. These rare clinical presentations may be associated with HAM/TSP (Biswas et al. 2009). HTLV-2 is endemic among Amerindians and has been reported at a high prevalence in intravenou ...
ISSN:1355-0284
1538-2443
DOI:10.1007/s13365-014-0280-4