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Frequencies of micronucleated lymphocytes and Epstein‐Barr virus contamination in Altai region residents living near the Semipalatinsk atomic testing ground
We assessed the frequencies of micronucleated lymphocytes in 3,036 individuals living in 16 settlements in the western part of the Altai region. The majority of individuals with significantly high frequencies of micronucleated lymphocytes were detected in settlements adjacent to the Semipalatinsk at...
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Published in: | Environmental and molecular mutagenesis 1998, Vol.31 (1), p.11-17 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | We assessed the frequencies of micronucleated lymphocytes in 3,036 individuals living in 16 settlements in the western part of the Altai region. The majority of individuals with significantly high frequencies of micronucleated lymphocytes were detected in settlements adjacent to the Semipalatinsk atomic testing ground (SATG). The most considerable genome instability was found in individuals born in the period of intensive testing at the SATG (1949 to 1962). Moreover, we determined that the residents of the settlements adjacent to the SATGhave significantly high levels of antibodies to potentially oncogenic Epstein‐Barr virus, in addition to high frequencies of micronucleated lymphocytes. The considerable Epstein‐Barr virus contamination among the residents in the radiation‐polluted zone around the SATG was supposed to be caused by immunodeficiency disorders in these individuals and was correlated with high frequencies of micronucleated cells. Environ. Mol. Mutagen. 31:11–17, 1998. © Wiley‐Liss, Inc. |
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ISSN: | 0893-6692 1098-2280 |
DOI: | 10.1002/(SICI)1098-2280(1998)31:1<11::AID-EM3>3.0.CO;2-E |