Demographic and familial characteristics of HTLV‐I infection among an isolated, highly endemic population of African origin in French Guiana

To determine the epidemiological characteristics of human T cell leukemia/lymphoma virus type I (HTLV‐I) infection in the endemic village of Maripasoula, French Guiana, 1,614 persons (83.2% of the population) aged 2 to 91 years (mean age 21) were studied from November 1994 through April 1995. Plasma...

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Bibliographic Details
Published in:International journal of cancer 1998-05, Vol.76 (3), p.331-336
Main Authors: Plancoulaine, Sabine, Buigues, René‐Pierre, Murphy, Edward L., van Beveren, Monique, Pouliquen, Jean‐François, Joubert, Michel, Rémy, Franck, Tuppin, Philippe, Tortevoye, Patricia, De Thé, Guy, Moreau, Jean‐Paul, Gessain, Antoine
Format: Article
Language:English
Subjects:
Biological and medical sciences
Human viral diseases
Infectious diseases
Medical sciences
Viral diseases
Viral diseases of the nervous system
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Summary:To determine the epidemiological characteristics of human T cell leukemia/lymphoma virus type I (HTLV‐I) infection in the endemic village of Maripasoula, French Guiana, 1,614 persons (83.2% of the population) aged 2 to 91 years (mean age 21) were studied from November 1994 through April 1995. Plasma samples were screened by an HTLV‐I ELISA and an IFA test (on MT2 cells), and positive samples were tested by an HTLV‐I and ‐II type‐specific Western blot. Overall seropositivity in the village was 6.7%, but HTLV‐I infection was restricted to 3 of 6 ethnic groups, including the Noir‐Marron (descendants of escaped African slaves, 8%), the Creoles (4.1%) and those of mixed Noir Marron/other ethnicity (3.6%). In the Noir‐Marron population of 1,222 persons, including 606 men and 616 women and representing 76% of those tested, HTLV‐I seroprevalence increased significantly with age in both sexes, reaching 40% in women older than 50 years. Univariate risk factors for HTLV‐I seropositivity in women included older age, more pregnancies, more live births and a history of hospitalization. A cross‐sectional analysis of sexual partners demonstrated an excess of discordant female HTLV‐I+/male HTLV‐I− couples, indicating preferential male‐to‐female sexual transmission. The demonstration of 11 HTLV‐I‐seropositive children aged less than 15 years, of whom 9 had a seropositive mother, suggested maternal–child HTLV‐I transmission. Our results demonstrate a very high seroprevalence of HTLV‐I in this South American population descended from African slaves, probably due to high rates of mother‐to‐child and sexual transmission within this rather isolated group. Int. J. Cancer 76:331–336, 1998.© 1998 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/(SICI)1097-0215(19980504)76:3<331::AID-IJC8>3.0.CO;2-W