Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Tumor necrosis factor-α (TNF-α) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-α messenger RNA expression was observed in adipose tissue from four different rodent models of obesity and diabetes. TNF-α protein was also elevated locally and system...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1993-01, Vol.259 (5091), p.87-91
Main Authors: Hotamisligil, Gökhan S., Shargill, Narinder S., Spiegelman, Bruce M.
Format: Article
Language:English
Subjects:
3T3 Cells
Adipocytes
Adipose tissue
Adipose Tissue - physiology
Adipose Tissue - physiopathology
Adipose tissues
Animals
Biological and medical sciences
Blood Glucose - metabolism
Blotting, Northern
Diabetes
Diabetes Mellitus, Experimental - physiopathology
Glucose Clamp Technique
Homeostasis
Immunoglobulin G - genetics
Immunoglobulin G - pharmacology
Insulin
Insulin - pharmacology
Insulin Infusion Systems
Insulin resistance
Insulin Resistance - genetics
Male
Medical sciences
Messenger RNA
Metabolic diseases
Mice
Mice, Obese
Obesity
Obesity - chemically induced
Obesity - genetics
Obesity - physiopathology
Rats
Rats, Zucker
Receptors, Cell Surface - genetics
Receptors, Cell Surface - physiology
Receptors, Tumor Necrosis Factor
Recombinant Fusion Proteins - pharmacology
Reference Values
RNA
RNA - genetics
RNA - isolation & purification
RNA, Messenger - biosynthesis
RNA, Messenger - isolation & purification
Sodium Glutamate
Tumor necrosis factor
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - genetics
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Summary:Tumor necrosis factor-α (TNF-α) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-α messenger RNA expression was observed in adipose tissue from four different rodent models of obesity and diabetes. TNF-α protein was also elevated locally and systemically. Neutralization of TNF-α in obese fa/fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. These results indicate a role for TNF-α in obesity and particularly in the insulin resistance and diabetes that often accompany obesity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7678183