Lead Intoxication Under Environmental Hypoxia Impairs Oral Health

We have reported that chronic lead intoxication under hypoxic environment induces alveolar bone loss that can lead to periodontal damage with the subsequent loss of teeth. The aim of the present study was to assess the modification of oral inflammatory parameters involved in the pathogenesis of peri...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2014, Vol.77 (21), p.1304-1310
Main Authors: Terrizzi, Antonela R., Fernandez-Solari, Javier, Lee, Ching M., Martínez, María Pilar, Conti, María Ines
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - chemically induced
Alveolar Bone Loss - pathology
Angiogenesis
Animals
Biomarkers - metabolism
Bones
Damage
Dinoprostone - metabolism
Environmental conditions
Female
Gingiva - pathology
Health
Hypoxia
Hypoxia - complications
Hypoxia - pathology
Intoxication
Lead
Lead - toxicity
Mathematical models
Nitric Oxide Synthase Type II - metabolism
Oral Health
Pathogenesis
Periodontitis - chemically induced
Periodontitis - pathology
Populations
Rats
Rats, Wistar
Submandibular Gland - drug effects
Submandibular Gland - metabolism
Teeth
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have reported that chronic lead intoxication under hypoxic environment induces alveolar bone loss that can lead to periodontal damage with the subsequent loss of teeth. The aim of the present study was to assess the modification of oral inflammatory parameters involved in the pathogenesis of periodontitis in the same experimental model. In gingival tissue, hypoxia increased inducible nitric oxid synthase (iNOS) activity (p < .01) and meanwhile lead decreased prostaglandin E 2 (PGE 2 ) content (p < .05). In submandibular gland (SMG), iNOS activity was enhanced by lead and PGE 2 content was increased by both lead and hypoxia (p < .01) and even more by combined treatments (p < .001). In the SMG, hypoxia stimulated angiogenesis (p < .01) with blood extravasation. Adrenal glands were 22% bigger in those animals exposed to lead under hypoxic conditions. Results suggest a wide participation of inflammatory markers that mediate alveolar bone loss induced by these environmental conditions. The lack of information regarding oral health in lead-contaminated populations that coexist with hypoxia induced us to evaluate the alteration of inflammatory parameters in rat oral tissues to elucidate the link between periodontal damage and these environmental conditions.
ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287394.2014.938209