Determination of major metabolites of MAM-2201 and JWH-122 in in vitro and in vivo studies to distinguish their intake

Highlights • Main metabolites of JWH-122 and MAM-2201 were identified. • Some JWH-122 metabolites were detected in in vitro study with MAM-2201. • Relative concentrations of N -5- and N -4-hydroxylated metabolites should be considered. • This study will be useful for the determination of JWH-122 and...

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Bibliographic Details
Published in:Forensic science international 2014-11, Vol.244, p.85-91
Main Authors: Jang, Moonhee, Shin, Ilchung, Yang, Wonkyung, Chang, Hyejin, Yoo, Hye Hyun, Lee, Jaesin, Kim, Eunmi
Format: Article
Language:English
Subjects:
Biomedical materials
Fluorination
Humans
Hydroxylation
In vitro metabolism
In Vitro Techniques
In vitro testing
In vivo testing
In vivo tests
Indoles - analysis
Indoles - chemistry
JWH-122
MAM-2201
Metabolism
Metabolites
Microsomes, Liver - chemistry
Molecular Structure
Naphthalenes - analysis
Naphthalenes - chemistry
Pathology
Street Drugs - analysis
Street Drugs - chemistry
Surgical implants
Synthetic cannabinoid
Urine
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Summary:Highlights • Main metabolites of JWH-122 and MAM-2201 were identified. • Some JWH-122 metabolites were detected in in vitro study with MAM-2201. • Relative concentrations of N -5- and N -4-hydroxylated metabolites should be considered. • This study will be useful for the determination of JWH-122 and MAM-2201 abuse.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2014.08.008