1H NMR-based metabolomics studies on the effect of sesamin in Atlantic salmon (Salmo salar)

•1H NMR-based metabolomics is a useful tool in animal studies.•Effect of dietary sesamin on the tissue metabolic profiles of salmon was studied.•Sesamin inclusion increases liver intermediates of the TCA cycle.•Muscle energy metabolism is affected by dietary sesamin levels. A 1H NMR-based metabolomi...

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Bibliographic Details
Published in:Food chemistry 2014-03, Vol.147, p.98-105
Main Authors: Wagner, Liane, Trattner, Sofia, Pickova, Jana, Gómez-Requeni, Pedro, Moazzami, Ali A.
Format: Article
Language:English
Subjects:
Aquaculture
Atlantic salmon
Bioactive compounds
Biological and medical sciences
Fish
Food toxicology
Inclusions
Liver
Marine
Medical sciences
Metabolism
Metabolites
Metabolomics
Muscles
NMR
Phases
Salmo salar
Salmon
Sesamin
Teleost
Toxicology
Vegetable oil
White muscle
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Summary:•1H NMR-based metabolomics is a useful tool in animal studies.•Effect of dietary sesamin on the tissue metabolic profiles of salmon was studied.•Sesamin inclusion increases liver intermediates of the TCA cycle.•Muscle energy metabolism is affected by dietary sesamin levels. A 1H NMR-based metabolomics approach was used to explore the impact of dietary sesamin on the liver and white muscle metabolic profile of Atlantic salmon (Salmo salar). Fish were fed diets containing different n-6/n-3 fatty acid ratios (V0.5 or V1) and sesamin contents [without (S0), low (SL) 1.16g/kg feed, and high (SH) 5.8g/kg feed] for 4months. Liver and white muscle extracts of aqueous polar and chloroform lipid phases were collected. Multivariate data analyses (PCA and OPLS-DA) of liver chloroform phase showed that high levels of sesamin affected the metabolic profile impartially of the n-6/n-3 ratio. In the aqueous phase, the metabolome of liver and white muscle were affected in fish fed an n-6/n-3 ratio of 1.0 and 0.5, respectively. With high inclusion of sesamin, the levels of several metabolites (e.g. glucose, glycogen, leucine, valine, creatine, carnitine, lactate, nucleosides) were increased. These metabolites are mainly associated with energy metabolism, suggesting that high sesamin inclusion affects liver and white muscle metabolism in fish. This is consistent with lower body weights found in fish fed high sesamin content.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2013.09.128