Fabrication of calcium phosphate fibres through electrospinning and sintering of hydroxyapatite nanoparticles

Calcium phosphate (CaP) materials such as synthetic hydroxyapatite (HA, Ca10(PO4)6·(OH)2) and β-tricalcium phosphate (β-TCP, Ca3(PO4)2) are well-known for their potential in bone tissue engineering and drug delivery applications. Processing such materials into submicrofibres might contribute to impr...

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Bibliographic Details
Published in:Materials letters 2013-09, Vol.106, p.145-150
Main Authors: Mouthuy, Pierre-Alexis, Crossley, Alison, Ye, Hua
Format: Article
Language:English
Subjects:
biocompatibility
Biomedical materials
Calcium phosphate
Composites
drug delivery systems
electron microscopy
Electrospinning
Fibers
Fibres
Fourier transform infrared spectroscopy
heat treatment
Hydroxyapatite
Hydroxyapatite nanoparticles
Nanoparticles
new methods
PLGA
polymers
Sintering
Surgical implants
temperature
tissue engineering
tricalcium phosphate
X-ray diffraction
X-ray photoelectron spectroscopy
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Summary:Calcium phosphate (CaP) materials such as synthetic hydroxyapatite (HA, Ca10(PO4)6·(OH)2) and β-tricalcium phosphate (β-TCP, Ca3(PO4)2) are well-known for their potential in bone tissue engineering and drug delivery applications. Processing such materials into submicrofibres might contribute to improve their biocompatibility. This paper presents a new method for creating CaP submicrofibres through the electrospinning route. A thermal treatment at sintering temperature (1100°C) was applied to electrospun polymer fibres filled with hydroxyapatite nanoparticles to cause aggregation of the nanoparticles and vaporise the polymer matrix. The images taken by electron microscopy revealed that the treated samples maintained their submicrofibrous morphology. Moreover, Fourier transform infrared spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy analysis confirmed that the resulting fibres are made of hydroxypatite and tricalcium phosphates. •CaP submicrofibres can be produced by using a combination of electrospinning and sintering.•Electrospun fibres were produced from a PLGA solution highly concentrated with HA nanoparticles.•Heat treatments were applied to evaporate the polymer and induce sintering of the nanoparticles.•Hydroxypatite was identified to be the main material in the sintered scaffold.•Approach potentially applicable to make submicrofibres from a variety of ceramic material.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2013.04.110