Erythrocyte Sedimentation Rate as Baseline Predictor for the Development of Uveitis in Children With Juvenile Idiopathic Arthritis

Purpose To analyze inflammatory parameters as possible predictors for the development of uveitis in juvenile idiopathic arthritis (JIA) patients. Further, to analyze the predictive value of demographic and clinical factors at the onset of arthritis. Design Retrospective cohort study. Methods In 358...

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Bibliographic Details
Published in:	American journal of ophthalmology 2015-02, Vol.159 (2), p.372-377.e1
Main Authors:	Haasnoot, Arenda J.W, van Tent-Hoeve, Maretta, Wulffraat, Nico M, Schalij-Delfos, Nicoline E, Los, Leonoor I, Armbrust, Wineke, Zuithoff, Nicolaas P.A, de Boer, Joke H
Format:	Article
Language:	eng
Subjects:	Age Age of Onset Antibodies, Antinuclear - blood Antigens Arthritis Arthritis, Juvenile - blood Biomarkers - blood Blood Sedimentation C-Reactive Protein - metabolism Child Child, Preschool Cohort Studies Confidence intervals Female HLA-B27 Antigen - blood Humans Infant Leukocyte Count Male Multivariate analysis Ophthalmology Pediatrics Retrospective Studies Rheumatic diseases Studies Uveitis - blood Variables
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Summary:	Purpose To analyze inflammatory parameters as possible predictors for the development of uveitis in juvenile idiopathic arthritis (JIA) patients. Further, to analyze the predictive value of demographic and clinical factors at the onset of arthritis. Design Retrospective cohort study. Methods In 358 children with oligoarthritis and rheumatoid factor–negative polyarthritis, erythrocyte sedimentation rate (ESR), C-reactive protein, leukocyte count, presence of antinuclear antibodies (ANA), presence of human leukocyte antigen (HLA-)B27, age of onset of JIA, and sex were analyzed for their predictive value for the onset of uveitis. Results One hundred forty-seven patients (41%) were diagnosed with chronic anterior uveitis. Young age of onset, presence of ANA, and elevated ESR appeared to be predictive factors according to univariate analyses ( P = .029, P = .007, and P = 5E−4 , respectively). According to multivariate analysis, young age of onset and elevated ESR appeared to be predictive after adjusting for the other relevant factors ( P = .004 and P = .001, respectively). A prediction model was developed. Conclusions Elevated ESR appears to be a predictor for the occurrence of uveitis in patients with JIA. Since ESR is already routinely tested in patients with recently diagnosed arthritis, its use as a biomarker can easily be implemented in daily practice.
ISSN:	0002-9394 1879-1891