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effects of essential oil of Mentha x villosa on skeletal muscle of the toad
The effects of the essential oil of Mentha x villosa (EOMV) was investigated in saponin‐permeabilized fibres and in intact sartorius muscle of the toad. In intact muscle EOMV at concentrations from 1 to 100 μg/mL blocked the contraction induced by high (80 mM) potassium and induced potentiation of c...
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Published in: | Phytotherapy research 1997-12, Vol.11 (8), p.552-557 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | The effects of the essential oil of Mentha x villosa (EOMV) was investigated in saponin‐permeabilized fibres and in intact sartorius muscle of the toad. In intact muscle EOMV at concentrations from 1 to 100 μg/mL blocked the contraction induced by high (80 mM) potassium and induced potentiation of caffeine‐induced muscle contraction. From 1 to 6 mg/mL EOMV elicited contraction in both depolarized (by 110 mM K+) and non‐depolarized (4 mM K+) muscle fibres. This contraction was blocked by procaine. At 3 mg/mL EOMV depolarized the normal resting potential from −80.77 to −71.21 mV, but did not alter the transmembrane potential in the presence of 60 mM K+. EOMV (1 mg/mL) induced contraction of saponin‐permeabilized muscle fibres with an intact sarcoplasmic reticulum (SR). These data suggest that EOMV: (i) induces muscle contraction by releasing Ca2+ from SR; (ii) impairs the excitation–contraction coupling at a step before Ca2+ release from the SR. © 1997 John Wiley & Sons, Ltd. |
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ISSN: | 0951-418X 1099-1573 |
DOI: | 10.1002/(SICI)1099-1573(199712)11:8<552::AID-PTR154>3.0.CO;2-N |