Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives

Controlled modification of the carboxylic acid moieties of hyaluronic acid with mono- and polyfunctional hydrazides leads to biochemical probes, biopolymers with altered physical and chemical properties, tethered drugs for controlled release, and crosslinked hydrogels as biocompatible scaffoldings f...

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Bibliographic Details
Published in:Journal of controlled release 1998-04, Vol.53 (1), p.93-103
Main Authors: Prestwich, Glenn D, Marecak, Dale M, Marecek, James F, Vercruysse, Koen P, Ziebell, Michael R
Format: Article
Language:English
Subjects:
Biocompatible hydrogel
Biocompatible Materials
Biodegradation, Environmental
Biological and medical sciences
Biomaterial
Bones, joints and connective tissue. Antiinflammatory agents
Cross-Linking Reagents - chemistry
General pharmacology
Hyaluronic Acid - chemical synthesis
Hyaluronic Acid - chemistry
Hyaluronidase
Hydrazones - chemistry
Hydrocortisone
Medical sciences
Molecular Structure
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyfunctional crosslinker
Spectrum Analysis
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Summary:Controlled modification of the carboxylic acid moieties of hyaluronic acid with mono- and polyfunctional hydrazides leads to biochemical probes, biopolymers with altered physical and chemical properties, tethered drugs for controlled release, and crosslinked hydrogels as biocompatible scaffoldings for tissue engineering. Methods for polyhydrazide synthesis, for prodrug preparation, for hydrogel crosslinking, and for monitoring biodegradation are described.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(97)00242-3