DNA methylation of the LEP gene is associated with craving during alcohol withdrawal

Highlights • We investigated DNA methylation patterns of the leptin gene promoter region in alcohol dependent patients. • Low methylation status is associated with increasing serum leptin levels during withdrawal. • low methylation status is associated with an elevation of alcohol craving during wit...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2015-01, Vol.51, p.371-377
Main Authors: Hillemacher, Thomas, Weinland, Christian, Lenz, Bernd, Kraus, Thomas, Heberlein, Annemarie, Glahn, Alexander, Muschler, Marc A.N, Bleich, Stefan, Kornhuber, Johannes, Frieling, Helge
Format: Article
Language:English
Subjects:
Adult
Alcohol dependence
Alcoholism - blood
Alcoholism - genetics
Craving
Craving - physiology
DNA Methylation
Endocrinology & Metabolism
Epigenetics
Female
Genetic Association Studies
Humans
Leptin
Leptin - blood
Leptin - genetics
Male
Middle Aged
Promoter Regions, Genetic
Psychiatry
Substance Withdrawal Syndrome - blood
Substance Withdrawal Syndrome - genetics
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Summary:Highlights • We investigated DNA methylation patterns of the leptin gene promoter region in alcohol dependent patients. • Low methylation status is associated with increasing serum leptin levels during withdrawal. • low methylation status is associated with an elevation of alcohol craving during withdrawal.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2014.10.014