Reliable assessment of liver function using LiMAx

Abstract Background13 C-liver function breath tests can facilitate the assessment of hepatic function in-vivo and may help surgeons to identify candidates for safe liver surgery. However, their acceptance into clinical practice is dependent on evaluation of technical efficacy and repeatability. The...

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Bibliographic Details
Published in:The Journal of surgical research 2015-01, Vol.193 (1), p.184-189
Main Authors: Jara, Maximilian, MD, Bednarsch, Jan, Valle, Erika, Lock, Johan Friso, MD, PhD, Malinowski, Maciej, MD, PhD, Schulz, Antje, MD, PhD, Seehofer, Daniel, MD, PhD, Jung, Tobias, MD, Stockmann, Martin, MD, PhD
Format: Article
Language:English
Subjects:
Abdomen - surgery
Acetamides
Adult
Breath Tests - methods
Carbon Dioxide - metabolism
Carbon Isotopes
Elective Surgical Procedures
Female
Healthy Volunteers
Humans
Intra-individual repeatability
Liver function
Liver function test
Liver Function Tests - methods
Liver Function Tests - standards
Male
Models, Biological
Preoperative Care - methods
Preoperative Care - standards
Reference Values
Reproducibility of Results
Surgery
Within-subject repeatability
Young Adult
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Summary:Abstract Background13 C-liver function breath tests can facilitate the assessment of hepatic function in-vivo and may help surgeons to identify candidates for safe liver surgery. However, their acceptance into clinical practice is dependent on evaluation of technical efficacy and repeatability. The aims of this study were to evaluate the within-subject repeatability of the LiMAx (maximum liver function capacity) test in healthy individuals and in surgical patients to determine liver function in the perioperative workup. Material and methods The LiMAx test, which is based on intravenous injection of13 C-methacetin at a dosage of 2 mg/kg body weight was performed in eighty-six healthy subjects to determine a reference range. Twenty-four subjects underwent repeat LiMAx testing the following day to assess within-subject repeatability. Twenty-one patients undergoing elective extra-abdominal surgery under general anesthesia (GA group) received pre- and post-operative examinations. Results The normal range of LiMAx was found to be 430 ± 86 μg/kg/h and revealed a one-sided cut-off value of 315 μg/kg/h. The intraclass correlation coefficient of the repeat LiMAx tests was 0.85 (95% confidence interval 0.69–0.93) in the control group and 0.81 (95% confidence interval 0.60–0.92) in the group of patients with GA. Conclusions The LiMAx test shows excellent reproducibility in subjects with normal liver function. GA has no effect on test results.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2014.07.041