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The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage
Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failur...
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| Published in: | Neurocritical care 2014-12, Vol.21 (3), p.551-559 |
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| creator | Jaja, Blessing N. R. Attalla, Daniel Macdonald, R. Loch Schweizer, Tom A. Cusimano, Michael D. Etminan, Nima Hanggi, Daniel Hasan, David Johnston, S. Claiborne Le Roux, Peter Lo, Benjamin Louffat-Olivares, Ada Mayer, Stephan Molyneux, Andrew Noble, Adam Quinn, Audrey Schenk, Thomas Spears, Julian Singh, Jeffrey Todd, Michael Torner, James Tseng, Ming van den Bergh, William Vergouwen, Mervyn D. I. Wong, George K. C. |
| description | Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets. |
| doi_str_mv | 10.1007/s12028-014-9990-y |
| format | article |
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R. ; Attalla, Daniel ; Macdonald, R. Loch ; Schweizer, Tom A. ; Cusimano, Michael D. ; Etminan, Nima ; Hanggi, Daniel ; Hasan, David ; Johnston, S. Claiborne ; Le Roux, Peter ; Lo, Benjamin ; Louffat-Olivares, Ada ; Mayer, Stephan ; Molyneux, Andrew ; Noble, Adam ; Quinn, Audrey ; Schenk, Thomas ; Spears, Julian ; Singh, Jeffrey ; Todd, Michael ; Torner, James ; Tseng, Ming ; van den Bergh, William ; Vergouwen, Mervyn D. I. ; Wong, George K. C.</creator><creatorcontrib>Jaja, Blessing N. R. ; Attalla, Daniel ; Macdonald, R. Loch ; Schweizer, Tom A. ; Cusimano, Michael D. ; Etminan, Nima ; Hanggi, Daniel ; Hasan, David ; Johnston, S. Claiborne ; Le Roux, Peter ; Lo, Benjamin ; Louffat-Olivares, Ada ; Mayer, Stephan ; Molyneux, Andrew ; Noble, Adam ; Quinn, Audrey ; Schenk, Thomas ; Spears, Julian ; Singh, Jeffrey ; Todd, Michael ; Torner, James ; Tseng, Ming ; van den Bergh, William ; Vergouwen, Mervyn D. I. ; Wong, George K. 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C.</creatorcontrib><title>The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage</title><title>Neurocritical care</title><addtitle>Neurocrit Care</addtitle><addtitle>Neurocrit Care</addtitle><description>Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. 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R.</au><au>Attalla, Daniel</au><au>Macdonald, R. Loch</au><au>Schweizer, Tom A.</au><au>Cusimano, Michael D.</au><au>Etminan, Nima</au><au>Hanggi, Daniel</au><au>Hasan, David</au><au>Johnston, S. Claiborne</au><au>Le Roux, Peter</au><au>Lo, Benjamin</au><au>Louffat-Olivares, Ada</au><au>Mayer, Stephan</au><au>Molyneux, Andrew</au><au>Noble, Adam</au><au>Quinn, Audrey</au><au>Schenk, Thomas</au><au>Spears, Julian</au><au>Singh, Jeffrey</au><au>Todd, Michael</au><au>Torner, James</au><au>Tseng, Ming</au><au>van den Bergh, William</au><au>Vergouwen, Mervyn D. I.</au><au>Wong, George K. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage</atitle><jtitle>Neurocritical care</jtitle><stitle>Neurocrit Care</stitle><addtitle>Neurocrit Care</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>21</volume><issue>3</issue><spage>551</spage><epage>559</epage><pages>551-559</pages><issn>1541-6933</issn><eissn>1556-0961</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24865271</pmid><doi>10.1007/s12028-014-9990-y</doi><tpages>9</tpages></addata></record> |
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| subjects | Aneurysms Biomedical Research Clinical trials Critical Care Medicine Data dictionaries Databases, Factual Datasets Fatalities Hemorrhage Humans Intensive Internal Medicine Medicine Medicine & Public Health Neurology Observational studies Patients Post traumatic stress disorder Prospective Studies Randomized Controlled Trials as Topic Registries Review Article Subarachnoid Hemorrhage - therapy Treatment Outcome Variables |
| title | The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage |
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