The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage

Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failur...

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Bibliographic Details
Published in:Neurocritical care 2014-12, Vol.21 (3), p.551-559
Main Authors: Jaja, Blessing N. R., Attalla, Daniel, Macdonald, R. Loch, Schweizer, Tom A., Cusimano, Michael D., Etminan, Nima, Hanggi, Daniel, Hasan, David, Johnston, S. Claiborne, Le Roux, Peter, Lo, Benjamin, Louffat-Olivares, Ada, Mayer, Stephan, Molyneux, Andrew, Noble, Adam, Quinn, Audrey, Schenk, Thomas, Spears, Julian, Singh, Jeffrey, Todd, Michael, Torner, James, Tseng, Ming, van den Bergh, William, Vergouwen, Mervyn D. I., Wong, George K. C.
Format: Article
Language:English
Subjects:
Aneurysms
Biomedical Research
Clinical trials
Critical Care Medicine
Data dictionaries
Databases, Factual
Datasets
Fatalities
Hemorrhage
Humans
Intensive
Internal Medicine
Medicine
Medicine & Public Health
Neurology
Observational studies
Patients
Post traumatic stress disorder
Prospective Studies
Randomized Controlled Trials as Topic
Registries
Review Article
Subarachnoid Hemorrhage - therapy
Treatment Outcome
Variables
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Summary:Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets.
ISSN:1541-6933
1556-0961
DOI:10.1007/s12028-014-9990-y