Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation

Highlight ► Reduced circulating tryptophan concentrations observed in depressed patients occur independent of IDO induction and kynurenine pathway activation.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2012-08, Vol.26 (6), p.979-987
Main Authors: Hughes, Martina M, Carballedo, Angela, McLoughlin, Declan M, Amico, Francesco, Harkin, Andrew, Frodl, Thomas, Connor, Thomas J
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Biomarkers - analysis
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Chromatography, High Pressure Liquid
Cytokine
Cytokines - blood
Depression
Depressive Disorder, Major - metabolism
Female
Humans
IDO
IFN-γ
IL-1
IL-6
Inflammation
Kynurenine
Kynurenine - blood
Kynurenine - physiology
Male
Psychiatry
Real-Time Polymerase Chain Reaction
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Serotonin Plasma Membrane Transport Proteins - metabolism
SERT
Signal Transduction - physiology
TNF-α
Tryptophan - blood
Tryptophan - deficiency
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Description
Summary:Highlight ► Reduced circulating tryptophan concentrations observed in depressed patients occur independent of IDO induction and kynurenine pathway activation.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2012.05.010