Neuroprotective efficacy of subcutaneous insulin-like growth factor-I administration in normotensive and hypertensive rats with an ischemic stroke

Highlights • Systemic injection of IGF-I is neuroprotective in rats with ischemic stroke. • The neuroprotective effect of IGF-I is not mediated by the modulation of blood flow. • IGF-I is less effective in hypertensive rats than in normotensive controls. • IGF-I inhibits microglial activation in hyp...

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Bibliographic Details
Published in:Neuroscience 2013-10, Vol.250, p.253-262
Main Authors: De Geyter, D, Stoop, W, Sarre, S, De Keyser, J, Kooijman, R
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body Weight - drug effects
brain ischemia
Brain Ischemia - drug therapy
Brain Ischemia - pathology
endothelin-1
Endothelin-1 - pharmacology
Fundamental and applied biological sciences. Psychology
Glial Fibrillary Acidic Protein - metabolism
Glucose - metabolism
Humans
hypertension
Hypertension - drug therapy
Hypertension - pathology
IGF-I
Immunohistochemistry
Injections, Subcutaneous
Insulin-Like Growth Factor I - administration & dosage
Insulin-Like Growth Factor I - pharmacology
Laser-Doppler Flowmetry
Macrophage Activation - drug effects
Male
Medical sciences
Microglia - drug effects
Nervous System Diseases - physiopathology
Nervous System Diseases - psychology
neuroglia
Neurology
Neuroprotective Agents
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Recombinant Proteins - pharmacology
Stroke - drug therapy
Stroke - etiology
Stroke - pathology
Telemetry
Vascular diseases and vascular malformations of the nervous system
Vertebrates: nervous system and sense organs
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Summary:Highlights • Systemic injection of IGF-I is neuroprotective in rats with ischemic stroke. • The neuroprotective effect of IGF-I is not mediated by the modulation of blood flow. • IGF-I is less effective in hypertensive rats than in normotensive controls. • IGF-I inhibits microglial activation in hypertensive rats but not in control rats.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.07.016