Overexpression of Folate Biosynthesis Genes in Rice (Oryza sativa L.) and Evaluation of Their Impact on Seed Folate Content

Folate (vitamin B9) deficiency is a global health problem especially in developing countries where the major staple foods such as rice contain extremely low folates. Biofortification of rice could be an alternative complement way to fight folate deficiency. In this study, we evaluated the availabili...

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Bibliographic Details
Published in:Plant foods for human nutrition (Dordrecht) 2014-12, Vol.69 (4), p.379-385
Main Authors: Dong, Wei, Cheng, Zhi-jun, Lei, Cai-lin, Wang, Xiao-le, Wang, Jiu-lin, Wang, Jie, Wu, Fu-qing, Zhang, Xin, Guo, Xiu-ping, Zhai, Hu-qu, Wan, Jian-min
Format: Article
Language:English
Subjects:
biofortification
Biological and medical sciences
biosynthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
developing countries
Diet
Ecology
enzymes
Feeding. Feeding behavior
folic acid
Folic Acid - biosynthesis
Folic Acid - genetics
Folic Acid Deficiency - diet therapy
Food Science
Food, Fortified
Food, Genetically Modified
Fundamental and applied biological sciences. Psychology
gene overexpression
Genes, Plant
genetic background
genetically modified organisms
glutamates
Humans
Nutrition
Original Paper
Oryza - enzymology
Oryza - genetics
Oryza - metabolism
Oryza sativa
parents
Plant Physiology
Plants, Genetically Modified
rice
Seeds - metabolism
staple foods
Transaminases - genetics
Transgenes
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin B Complex - biosynthesis
Vitamin B Complex - genetics
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Summary:Folate (vitamin B9) deficiency is a global health problem especially in developing countries where the major staple foods such as rice contain extremely low folates. Biofortification of rice could be an alternative complement way to fight folate deficiency. In this study, we evaluated the availability of the genes in each step of folate biosynthesis pathway for rice folate enhancement in the japonica variety kitaake genetic background. The first enzymes GTP cyclohydrolase I (GTPCHI) and aminodeoxychorismate synthase (ADCS) in the pterin and para-aminobenzoate branches resulted in significant increase in seed folate content, respectively (P 
ISSN:0921-9668
1573-9104
DOI:10.1007/s11130-014-0450-9