Factors responsible for elevated plasma B-type natriuretic peptide levels in severe aortic stenosis: Comparison between elderly and younger patients

Abstract Background Elevated plasma B-type natriuretic peptide (BNP) is a predictor of outcome and helpful for risk stratification in aortic stenosis (AS). However, left ventricular (LV) diastolic dysfunction progresses with aging and may also influence plasma BNP levels in elderly patients. We hypo...

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Published in:Journal of cardiology 2014-12, Vol.64 (6), p.476-481
Main Authors: Sasaki, Shunsuke, MD, Daimon, Masao, MD, FACC, FJCC, Kawata, Takayuki, MD, Miyazaki, Sakiko, MD, Ichikawa, Ryoko, MD, Maruyama, Masaki, MD, Chiang, Shuo-Ju, MD, Mahara, Keitaro, MD, Watanabe, Hiroyuki, MD, FJCC, Sumiyoshi, Tetsuya, MD, FJCC, Tomoike, Hitonobu, MD, FJCC, Daida, Hiroyuki, MD, FJCC
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aging
Aortic stenosis
Aortic Valve Stenosis - blood
Aortic Valve Stenosis - diagnostic imaging
Aortic Valve Stenosis - physiopathology
Biomarkers - blood
Cardiac function
Cardiovascular
Echocardiography
Female
Humans
Male
Multivariate Analysis
Natriuretic Peptide, Brain - blood
Plasma B-type natriuretic peptide
Severity of Illness Index
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Summary:Abstract Background Elevated plasma B-type natriuretic peptide (BNP) is a predictor of outcome and helpful for risk stratification in aortic stenosis (AS). However, left ventricular (LV) diastolic dysfunction progresses with aging and may also influence plasma BNP levels in elderly patients. We hypothesized that plasma BNP levels may be influenced by age in severe AS, and that factors that affect the elevation of plasma BNP levels may be different between elderly and younger patients with AS. Methods We performed echocardiography in 341 patients with severe AS [aortic valve area (AVA) < 1.0 cm2 ] and classified them into two groups by age (elderly ≥75 years old, n = 201; younger patients
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2014.03.005