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Effects of acute hypercapnia with and without acidosis on lung inflammation and apoptosis in experimental acute lung injury
Highlights • Therapeutic hypercapnia with and without acidosis reduced diffuse alveolar damage. • Hypercapnia decreased interleukin-6 and interleukin-1β expressions. • Hypercapnia reduced fibrogenesis. • Hypercapnia, regardless of acidosis, decreased lung and kidney cell apoptosis.
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Published in: | Respiratory physiology & neurobiology 2015-01, Vol.205, p.1-6 |
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Main Authors: | , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • Therapeutic hypercapnia with and without acidosis reduced diffuse alveolar damage. • Hypercapnia decreased interleukin-6 and interleukin-1β expressions. • Hypercapnia reduced fibrogenesis. • Hypercapnia, regardless of acidosis, decreased lung and kidney cell apoptosis. |
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ISSN: | 1569-9048 1878-1519 |
DOI: | 10.1016/j.resp.2014.09.007 |