Effects of acute hypercapnia with and without acidosis on lung inflammation and apoptosis in experimental acute lung injury

Highlights • Therapeutic hypercapnia with and without acidosis reduced diffuse alveolar damage. • Hypercapnia decreased interleukin-6 and interleukin-1β expressions. • Hypercapnia reduced fibrogenesis. • Hypercapnia, regardless of acidosis, decreased lung and kidney cell apoptosis.

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2015-01, Vol.205, p.1-6
Main Authors: Nardelli, L.M, Rzezinski, A, Silva, J.D, Maron-Gutierrez, T, Ornellas, D.S, Henriques, I, Capelozzi, V.L, Teodoro, W, Morales, M.M, Silva, P.L, Pelosi, P, Garcia, C.S.N.B, Rocco, P.R.M
Format: Article
Language:English
Subjects:
Acidosis
Acute Disease
Acute Lung Injury - physiopathology
Alveolar collapse
Animals
Apoptosis
Buffers
Cytokines
Disease Models, Animal
Hydrogen-Ion Concentration
Hypercapnia
In Situ Nick-End Labeling
Lung injury
Medical Education
Pneumonia - physiopathology
Pulmonary/Respiratory
Rats
Rats, Wistar
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
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Summary:Highlights • Therapeutic hypercapnia with and without acidosis reduced diffuse alveolar damage. • Hypercapnia decreased interleukin-6 and interleukin-1β expressions. • Hypercapnia reduced fibrogenesis. • Hypercapnia, regardless of acidosis, decreased lung and kidney cell apoptosis.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2014.09.007