Surgical management of well-differentiated thyroid carcinoma in children and adolescents: 33 years of experience of a single institution in Serbia

Well-differentiated thyroid carcinoma in children and adolescents is rare but demonstrates aggressive behavior. Gross lymph node metastases and distant metastases are common upon first clinical presentation. During a 33-year period (1981-2014) at the Institute of Oncology and Radiology of Serbia, 62...

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Bibliographic Details
Published in:ENDOCRINE JOURNAL 2014, Vol.61(11), pp.1079-1086
Main Authors: Dzodic, Radan, Buta, Marko, Markovic, Ivan, Gavrilovic, Dusica, Matovic, Milovan, Djurisic, Igor, Milovanovic, Zorka, Pupic, Gordana, Tasic, Slobodan, Besic, Nikola
Format: Article
Language:eng ; jpn
Subjects:
Adolescent
Carcinoma, Papillary - pathology
Carcinoma, Papillary - surgery
Child
Disease-Free Survival
Female
Humans
Lung Neoplasms - secondary
Lymphatic Metastasis
Male
Neck Dissection
Pediatric thyroid cancer
Retrospective Studies
Serbia
Surgical treatment
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Well differentiated thyroid carcinoma
Young Adult
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Summary:Well-differentiated thyroid carcinoma in children and adolescents is rare but demonstrates aggressive behavior. Gross lymph node metastases and distant metastases are common upon first clinical presentation. During a 33-year period (1981-2014) at the Institute of Oncology and Radiology of Serbia, 62 children and adolescents underwent surgery due to well-differentiated thyroid carcinoma. Mean age was 16.7 (range 7-21) years. At the time of diagnosis 6% of patients had lung metastases. Total thyroidectomy or completion thyroidectomy was performed for all patients followed by central neck dissection and frozen section examination of jugular-carotid compartments. Median follow-up was 10.9 (range 0.69-33.05) years and median tumor size was 20 (range 2-60) mm. Papillary carcinoma was found in 96%, and follicular and Hürthle cell carcinoma in 2% of patients. Multifocal tumors were found in 50% and capsular invasion in 60% of patients. Lymphonodal metastases in either central or lateral neck compartments were found in 73% of patients. Multifocality and capsular invasion were significantly more frequent in patients less than 16 years of age (both p
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ14-0226